THO complex subunit 3 (THOC3)

About THO complex subunit 3

THO complex subunit 3 (THOC3) is a protein from Homo sapiens identified by UniProt accession Q96J01, 351 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	THO complex subunit 3
UniProt accession	Q96J01
Gene	THOC3
Organism	Homo sapiens
Length	351 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

chronotype measurement · score 0.27
vascular endothelial growth factor D measurement · score 0.16
deafness · score 0.05
neoplasm · score 0.03
triple-negative breast cancer · score 0.02
Red cell distribution width · score 0.02
cancer · score 0.02
squamous cell lung carcinoma · score 0.01
malaria · score 0.01
hepatocellular carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96J01-F1	alphafold	PREDICTED	90.20	—

Amino-acid sequence (351 residues)

MAVPAAAMGP SALGQSGPGS MAPWCSVSSG PSRYVLGMQE LFRGHSKTRE FLAHSAKVHS VAWSCDGRRL ASGSFDKTAS VFLLEKDRLV KENNYRGHGD SVDQLCWHPS NPDLFVTASG DKTIRIWDVR TTKCIATVNT KGENINICWS PDGQTIAVGN KDDVVTFIDA KTHRSKAEEQ FKFEVNEISW NNDNNMFFLT NGNGCINILS YPELKPVQSI NAHPSNCICI KFDPMGKYFA TGSADALVSL WDVDELVCVR CFSRLDWPVR TLSFSHDGKM LASASEDHFI DIAEVETGDK LWEVQCESPT FTVAWHPKRP LLAFACDDKD GKYDSSREAG TVKLFGLPND S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards