E3 ubiquitin-protein ligase Itchy homolog (ITCH)

About E3 ubiquitin-protein ligase Itchy homolog

E3 ubiquitin-protein ligase Itchy homolog (ITCH) is a protein from Homo sapiens identified by UniProt accession Q96J02, 903 residues long. MolForge cross-references it against 0 known binders and 270 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase Itchy homolog
UniProt accession	Q96J02
Gene	ITCH
Organism	Homo sapiens
Length	903 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (270)

Diseases linked to this target (Open Targets).

syndromic multisystem autoimmune disease due to ITCH deficiency · score 0.77
severe acute respiratory syndrome · score 0.37
blood protein measurement · score 0.31
high density lipoprotein cholesterol measurement · score 0.30
neurodegenerative disease · score 0.29
appendicular lean mass · score 0.25
head and neck squamous cell carcinoma · score 0.24
endometrial cancer · score 0.23
breast adenocarcinoma · score 0.23
glomerular filtration rate · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96J02-F1	alphafold	PREDICTED	74.67	—

Amino-acid sequence (903 residues)

MSDSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT NSPKWKQPLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL DIYETLKSNN MKLEEVVVTL QLGGDKEPTE TIGDLSICLD GLQLESEVVT NGETTCSENG VSLCLPRLEC NSAISAHCNL CLPGLSDSPI SASRVAGFTG ASQNDDGSRS KDETRVSTNG SDDPEDAGAG ENRRVSGNNS PSLSNGGFKP SRPPRPSRPP PPTPRRPASV NGSPSATSES DGSSTGSLPP TNTNTNTSEG ATSGLIIPLT ISGGSGPRPL NPVTQAPLPP GWEQRVDQHG RVYYVDHVEK RTTWDRPEPL PPGWERRVDN MGRIYYVDHF TRTTTWQRPT LESVRNYEQW QLQRSQLQGA MQQFNQRFIY GNQDLFATSQ SKEFDPLGPL PPGWEKRTDS NGRVYFVNHN TRITQWEDPR SQGQLNEKPL PEGWEMRFTV DGIPYFVDHN RRTTTYIDPR TGKSALDNGP QIAYVRDFKA KVQYFRFWCQ QLAMPQHIKI TVTRKTLFED SFQQIMSFSP QDLRRRLWVI FPGEEGLDYG GVAREWFFLL SHEVLNPMYC LFEYAGKDNY CLQINPASYI NPDHLKYFRF IGRFIAMALF HGKFIDTGFS LPFYKRILNK PVGLKDLESI DPEFYNSLIW VKENNIEECD LEMYFSVDKE ILGEIKSHDL KPNGGNILVT EENKEEYIRM VAEWRLSRGV EEQTQAFFEG FNEILPQQYL QYFDAKELEV LLCGMQEIDL NDWQRHAIYR HYARTSKQIM WFWQFVKEID NEKRMRLLQF VTGTCRLPVG GFADLMGSNG PQKFCIEKVG KENWLPRSHT CFNRLDLPPY KSYEQLKEKL LFAIEETEGF GQE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards