About ATP-binding cassette sub-family C member 12
ATP-binding cassette sub-family C member 12 (ABCC12) is a protein
from Homo sapiens identified by UniProt accession
Q96J65, 1359 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | ATP-binding cassette sub-family C member 12 |
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| UniProt accession | Q96J65 |
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| Gene | ABCC12 |
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| Organism | Homo sapiens |
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| Length | 1359 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.33
- mean corpuscular hemoglobin concentration · score 0.29
- breast ductal adenocarcinoma · score 0.11
- mean corpuscular volume · score 0.10
- mean corpuscular hemoglobin · score 0.08
- sex hormone-binding globulin measurement · score 0.06
- central nervous system cancer · score 0.04
- red blood cell density measurement · score 0.02
- autism · score 0.02
- osteosarcoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96J65-F1 | alphafold | PREDICTED | 77.78 | — |
Amino-acid sequence (1359 residues)
MVGEGPYLIS DLDQRGRRRS FAERYDPSLK TMIPVRPCAR LAPNPVDDAG LLSFATFSWL TPVMVKGYRQ RLTVDTLPPL STYDSSDTNA KRFRVLWDEE VARVGPEKAS LSHVVWKFQR TRVLMDIVAN ILCIIMAAIG PTVLIHQILQ QTERTSGKVW VGIGLCIALF ATEFTKVFFW ALAWAINYRT AIRLKVALST LVFENLVSFK TLTHISVGEV LNILSSDSYS LFEAALFCPL PATIPILMVF CAAYAFFILG PTALIGISVY VIFIPVQMFM AKLNSAFRRS AILVTDKRVQ TMNEFLTCIR LIKMYAWEKS FTNTIQDIRR RERKLLEKAG FVQSGNSALA PIVSTIAIVL TLSCHILLRR KLTAPVAFSV IAMFNVMKFS IAILPFSIKA MAEANVSLRR MKKILIDKSP PSYITQPEDP DTVLLLANAT LTWEHEASRK STPKKLQNQK RHLCKKQRSE AYSERSPPAK GATGPEEQSD SLKSVLHSIS FVVRKGKILG ICGNVGSGKS SLLAALLGQM QLQKGVVAVN GTLAYVSQQA WIFHGNVREN ILFGEKYDHQ RYQHTVRVCG LQKDLSNLPY GDLTEIGERG LNLSGGQRQR ISLARAVYSD RQLYLLDDPL SAVDAHVGKH VFEECIKKTL RGKTVVLVTH QLQFLESCDE VILLEDGEIC EKGTHKELME ERGRYAKLIH NLRGLQFKDP EHLYNAAMVE AFKESPAERE EDAGIIVLAP GNEKDEGKES ETGSEFVDTK VPEHQLIQTE SPQEGTVTWK TYHTYIKASG GYLLSLFTVF LFLLMIGSAA FSNWWLGLWL DKGSRMTCGP QGNRTMCEVG AVLADIGQHV YQWVYTASMV FMLVFGVTKG FVFTKTTLMA SSSLHDTVFD KILKSPMSFF DTTPTGRLMN RFSKDMDELD VRLPFHAENF LQQFFMVVFI LVILAAVFPA VLLVVASLAV GFFILLRIFH RGVQELKKVE NVSRSPWFTH ITSSMQGLGI IHAYGKKESC ITYHLLYFNC ALRWFALRMD VLMNILTFTV ALLVTLSFSS ISTSSKGLSL SYIIQLSGLL QVCVRTGTET QAKFTSVELL REYISTCVPE CTHPLKVGTC PKDWPSRGEI TFRDYQMRYR DNTPLVLDSL NLNIQSGQTV GIVGRTGSGK SSLGMALFRL VEPASGTIFI DEVDICILSL EDLRTKLTVI PQDPVLFVGT VRYNLDPFES HTDEMLWQVL ERTFMRDTIM KLPEKLQAEV TENGENFSVG ERQLLCVARA LLRNSKIILL DEATASMDSK TDTLVQNTIK DAFKGCTVLT IAHRLNTVLN CDHVLVMENG KVIEFDKPEV LAEKPDSAFA MLLAAEVRL
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