About Pleckstrin homology domain-containing family A member 8
Pleckstrin homology domain-containing family A member 8 (PLEKHA8) is a protein
from Homo sapiens identified by UniProt accession
Q96JA3, 519 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family A member 8 |
|---|
| UniProt accession | Q96JA3 |
|---|
| Gene | PLEKHA8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 519 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (16)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.25
- breast adenocarcinoma · score 0.25
- renal hypodysplasia/aplasia 3 · score 0.04
- hepatocellular carcinoma · score 0.04
- kidney disease · score 0.03
- multicystic dysplastic kidney · score 0.03
- Mayer-Rokitansky-Kuster-Hauser syndrome · score 0.03
- Joubert syndrome with oculorenal defect · score 0.03
- genito-palato-cardiac syndrome · score 0.03
- inflammatory biomarker measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JA3-F1 | alphafold | PREDICTED | 73.97 | — |
Amino-acid sequence (519 residues)
MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHSVDNTR MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT QKEKEFAENT ENLKTKMSEL RLYCDLLVQQ VDKTKEVTTT GVSNSEEGID VGTLLKSTCN TFLKTLEECM QIANAAFTSE LLYRTPPGSP QLAMLKSSKM KHPIIPIHNS LERQMELSTC ENGSLNMEIN GEEEILMKNK NSLYLKSAEI DCSISSEENT DDNITVQGEI RKEDGMENLK NHDNNLTQSG SDSSCSPECL WEEGKEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG PTVFAPVKMD LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS ATEALLWLKR GLKFLKGFLT EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR GVFALALRAA PSYEDFVAAL TVKEGDHQKE AFSIGMQRDL SLYLPAMEKQ LAILDTLYEV HGLESDEVV
Explore Pleckstrin homology domain-containing family A member 8 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets