About Hypermethylated in cancer 2 protein
Hypermethylated in cancer 2 protein (HIC2) is a protein
from Homo sapiens identified by UniProt accession
Q96JB3, 615 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Hypermethylated in cancer 2 protein |
|---|
| UniProt accession | Q96JB3 |
|---|
| Gene | HIC2 |
|---|
| Organism | Homo sapiens |
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| Length | 615 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- Heterotaxia · score 0.05
- left ventricular noncompaction · score 0.05
- reticulocyte measurement · score 0.05
- Aortic Coarctation · score 0.05
- atrioventricular septal defect 5 · score 0.04
- congenital heart disease · score 0.04
- atrial heart septal defect · score 0.04
- autosomal dominant coarctation of aorta · score 0.04
- familial thoracic aortic aneurysm and aortic dissection · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JB3-F1 | alphafold | PREDICTED | 49.06 | — |
Amino-acid sequence (615 residues)
MVSGPLALRW CAWAGRGDMG PDMELPSHSK QLLLQLNQQR TKGFLCDVII MVENSIFRAH KNVLAASSIY FKSLVLHDNL INLDTDMVSS TVFQQILDFI YTGKLLPSDQ PAEPNFSTLL TAASYLQLPE LAALCRRKLK RAGKPFGSGR AGSTGMGRPP RSQRLSTASV IQARYQGLVD GRKGAHAPQE LPQAKGSDDE LFLGGSNQDS VQGLGRAVCP AGGEAGLGGC SSSTNGSSGG CEQELGLDLS KKSPPLPPAT PGPHLTPDDA AQLSDSQHGS PPAASAPPVA NSASYSELGG TPDEPMDLEG AEDNHLSLLE APGGQPRKSL RHSTRKKEWG KKEPVAGSPF ERREAGPKGP CPGEEGEGVG DRVPNGILAS GAGPSGPYGE PPYPCKEEEE NGKDASEDSA QSGSEGGSGH ASAHYMYRQE GYETVSYGDN LYVCIPCAKG FPSSEQLNAH VETHTEEELF IKEEGAYETG SGGAEEEAED LSAPSAAYTA EPRPFKCSVC EKTYKDPATL RQHEKTHWLT RPFPCNICGK MFTQRGTMTR HMRSHLGLKP FACDECGMRF TRQYRLTEHM RVHSGEKPYE CQLCGGKFTQ QRNLISHLRM HTSPS
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