About CDK5 regulatory subunit-associated protein 3
CDK5 regulatory subunit-associated protein 3 (CDK5RAP3) is a protein
from Homo sapiens identified by UniProt accession
Q96JB5, 506 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | CDK5 regulatory subunit-associated protein 3 |
|---|
| UniProt accession | Q96JB5 |
|---|
| Gene | CDK5RAP3 |
|---|
| Organism | Homo sapiens |
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| Length | 506 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (196)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- vital capacity · score 0.26
- generalised epilepsy · score 0.20
- blood protein measurement · score 0.15
- neutrophil count · score 0.12
- neoplasm · score 0.11
- mean corpuscular hemoglobin · score 0.10
- hepatocellular carcinoma · score 0.10
- chronotype measurement · score 0.07
- body height · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JB5-F1 | alphafold | PREDICTED | 82.37 | — |
Amino-acid sequence (506 residues)
MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE SEEIAQLLSG SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI IALYEKDNTY LVELSSLLVR NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC QAGAAEMREQ FYHSCKQYGI TGENVRGELL ALVKDLPSQL AEIGAAAQQS LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE WRTGTEPSVV ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR NQFLDELMEL EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT MVSVLEDLIG KLTSLQLQHL FMILASPRYV DRVTEFLQQK LKQSQLLALK KELMVQKQQE ALEEQAALEP KLDLLLEKTK ELQKLIEADI SKRYSGRPVN LMGTSL
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