ELL-associated factor 1 (EAF1)

About ELL-associated factor 1

ELL-associated factor 1 (EAF1) is a protein from Homo sapiens identified by UniProt accession Q96JC9, 268 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	ELL-associated factor 1
UniProt accession	Q96JC9
Gene	EAF1
Organism	Homo sapiens
Length	268 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
lysosomal storage disease · score 0.27
melanoma · score 0.15
essential tremor · score 0.09
Young adult-onset Parkinsonism · score 0.07
Hereditary late-onset Parkinson disease · score 0.07
X-linked dystonia-parkinsonism · score 0.06
Cranio-cervical dystonia with laryngeal and upper-limb involvement · score 0.06
spinocerebellar ataxia type 15/16 · score 0.06
X-linked parkinsonism-spasticity syndrome · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96JC9-F1	alphafold	PREDICTED	70.74	—

Amino-acid sequence (268 residues)

MNGTANPLLD REEHCLRLGE SFEKRPRASF HTIRYDFKPA SIDTSCEGEL QVGKGDEVTI TLPHIPGSTP PMTVFKGNKR PYQKDCVLII NHDTGEYVLE KLSSSIQVKK TRAEGSSKIQ ARMEQQPTRP PQTSQPPPPP PPMPFRAPTK PPVGPKTSPL KDNPSPEPQL DDIKRELRAE VDIIEQMSSS SGSSSSDSES SSGSDDDSSS SGGEDNGPAS PPQPSHQQPY NSRPAVANGT SRPQGSNQLM NTLRNDLQLS ESGSDSDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards