1,5-anhydro-D-fructose reductase (AKR1E2)

About 1,5-anhydro-D-fructose reductase

1,5-anhydro-D-fructose reductase (AKR1E2) is a protein from Homo sapiens identified by UniProt accession Q96JD6, 320 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	1,5-anhydro-D-fructose reductase
UniProt accession	Q96JD6
Gene	AKR1E2
Organism	Homo sapiens
Length	320 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.32
mathematical ability · score 0.32
cortical surface area measurement · score 0.30
adolescent idiopathic scoliosis · score 0.27
PHF-tau measurement · score 0.27
allergic rhinitis · score 0.26
brain measurement · score 0.23
metabolite measurement · score 0.22
FEV/FVC ratio · score 0.18
red blood cell density measurement · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96JD6-F1	alphafold	PREDICTED	93.37	—

Amino-acid sequence (320 residues)

MGDIPAVGLS SWKASPGKVT EAVKEAIDAG YRHFDCAYFY HNEREVGAGI RCKIKEGAVR REDLFIATKL WCTCHKKSLV ETACRKSLKA LKLNYLDLYL IHWPMGFKPP HPEWIMSCSE LSFCLSHPRV QDLPLDESNM VIPSDTDFLD TWEAMEDLVI TGLVKNIGVS NFNHEQLERL LNKPGLRFKP LTNQIECHPY LTQKNLISFC QSRDVSVTAY RPLGGSCEGV DLIDNPVIKR IAKEHGKSPA QILIRFQIQR NVIVIPGSIT PSHIKENIQV FDFELTQHDM DNILSLNRNL RLAMFPITKN HKDYPFHIEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards