About Beta-galactoside alpha-2,6-sialyltransferase 2
Beta-galactoside alpha-2,6-sialyltransferase 2 (ST6GAL2) is a protein
from Homo sapiens identified by UniProt accession
Q96JF0, 529 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Beta-galactoside alpha-2,6-sialyltransferase 2 |
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| UniProt accession | Q96JF0 |
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| Gene | ST6GAL2 |
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| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (85)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.41
- self reported educational attainment · score 0.39
- cognitive function measurement · score 0.28
- neurofibrillary tangles measurement · score 0.28
- lifestyle measurement · score 0.27
- intelligence · score 0.26
- pancreatic adenocarcinoma · score 0.21
- hepatocellular carcinoma · score 0.08
- Monoamine oxidase A deficiency · score 0.06
- neoplasm · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JF0-F1 | alphafold | PREDICTED | 75.02 | — |
Amino-acid sequence (529 residues)
MKPHLKQWRQ RMLFGIFAWG LLFLLIFIYF TDSNPAEPVP SSLSFLETRR LLPVQGKQRA IMGAAHEPSP PGGLDARQAL PRAHPAGSFH AGPGDLQKWA QSQDGFEHKE FFSSQVGRKS QSAFYPEDDD YFFAAGQPGW HSHTQGTLGF PSPGEPGPRE GAFPAAQVQR RRVKKRHRRQ RRSHVLEEGD DGDRLYSSMS RAFLYRLWKG NVSSKMLNPR LQKAMKDYLT ANKHGVRFRG KREAGLSRAQ LLCQLRSRAR VRTLDGTEAP FSALGWRRLV PAVPLSQLHP RGLRSCAVVM SAGAILNSSL GEEIDSHDAV LRFNSAPTRG YEKDVGNKTT IRIINSQILT NPSHHFIDSS LYKDVILVAW DPAPYSANLN LWYKKPDYNL FTPYIQHRQR NPNQPFYILH PKFIWQLWDI IQENTKEKIQ PNPPSSGFIG ILIMMSMCRE VHVYEYIPSV RQTELCHYHE LYYDAACTLG AYHPLLYEKL LVQRLNMGTQ GDLHRKGKVV LPGFQAVHCP APSPVIPHS
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