About Leucine-rich repeat- and IQ domain-containing protein 1
Leucine-rich repeat- and IQ domain-containing protein 1 (LRRIQ1) is a protein
from Homo sapiens identified by UniProt accession
Q96JM4, 1722 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | Leucine-rich repeat- and IQ domain-containing protein 1 |
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| UniProt accession | Q96JM4 |
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| Gene | LRRIQ1 |
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| Organism | Homo sapiens |
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| Length | 1722 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- optic disc size measurement · score 0.30
- brain measurement · score 0.30
- vital capacity · score 0.29
- facial morphology measurement · score 0.26
- cortical surface area measurement · score 0.23
- synophrys measurement · score 0.19
- cortical thickness · score 0.18
- neuroimaging measurement · score 0.14
- forced expiratory volume · score 0.12
- unipolar depression · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JM4-F1 | alphafold | PREDICTED | 53.07 | — |
Amino-acid sequence (1722 residues)
MDDDDAKLKA EIEAELDKLS ISSLEKEDIE SDAKSETQSD DSDTDSVELP ESVLHCINII KNRSKAVEEL ILQDLEDTDI LSCSYGAVSN NHMHLRTGLS TEYEESSEQL IKILSEIEKE EFMRSKTDCA TPDFVPEPSP HDLPMDEHVL PDDADINFGY CEVEEKCRQS FEAWQEKQKE LEDKEKQTLK AQRDREEKQF QEEEEKRHCW MKQFKVEKKK LENIQKQEQD KMNDELYKEE KIWKEKFKQH EEYIRNLHLQ MEEERTRFKD QQEKEKNSLL KQQNNAAVKI QAKYKAFVAY QKYGPIIKEQ IESKKRKAQE WKEKEAKIRQ KEEENRKRLE EEQRIKEERK KQKEEERKRR EKEYEEKKNI VKQEREQLIS KEKIILREDA SQQLIISSAL KKSGYNNKHL SLEDISNDKG DIAKNLVDEN SKKQEDVLLW LVEESNMKEN VDRQTILKES IQVKLKESIS SQTILADFKM EEKNENLAKK RCSEELVKQE RKYENTDNKT ELGNSDLKGN LKEQFPLQEL KSDAQKEEKI MKHVINENTG QKTQIILGHN QEISEVKTNE EQKIIKDNQQ KKIQKVEKEE IQEQNGLLYK DKDTLVISVK QRSLSLTSEN SKDVRENVIL QEKEIYSKSK EIEENPKDNA WNSGIVIFNT TDTMINIEGK RNDQDYVLGR HAPCEGLSNY NAESSMVSKE VNSLKSEIRN ISEKCHENAP EPDSMTCCVS ESTLLYSIEE RRLAWIKSFK PWLEIFKQNQ QKKIVRRKRP VKCPANMTPA LDKLEILRCG PWDTLQQVTT VTFQDLPGCV LSTLAECTNL QFLSLRRCGL TSLHSLSNCK KLKYIDAQEN HIEAIECENL ENLCVVLLNK NQLTSLHGLD GCTNIQCLEL SYNKITRIGY SFFLEEKLVD NAGFCHHLGT STSYLSLAQV WIPTGLCWSW IPITSLTKNS DCNFLISHLY WNCGLESLKN LQQLILDHNQ LINTKGLCDT PTIVYLDCSH NHLTDVEGVE NCGLLQILKL QGNYLSELPS LENLVLLREL HLDDNSISTV EAFSSYWLPL LQNITISQNS LTKIVPLFHF VSLEKLDVSH NCLSDLKSAI KWFDACYSLH ELSLTGNPLL QETNWRDSLL KVLPALRILN GNILNSNSES RTEEHNQLGS AGFLALCQSQ IREFNLLIEN YITGKGDVFT LDTAENLCHY FKKLMILSTE YRHAHERGDV TITKKDESEA QKNHLAPTNS DSTLQNGVFY SCAREGEPDS PDIPEKWMDS VSSHSPLSKS ATCENMEGRH QEILVCQKRE DSKASSIPTI RIPFKEVVMT NSLLRNHQNI EPSEKIMAAV VIQSYWRGYL MRRQTHFSTR LHTAATEGLP NSSIKNQTIL KKGKRENIVN IRKQREKAAI LIQAVWKGFI LRKKLTTALE AIKNEESDEE YREIDLEDFI FDEAALEEEW LALDSTRFPS QTLLLSNQLH WPKIPGNLKW DDTSFNLPSN PAQAWLCNDK ENLSSSEHTQ FNSRSENKTS SWTPESKTSR KSLLKSEKEK KISEEWGFKD ISTAQQMLKR AQKMKSKKLK KKIDSTVRLA LFKNNENKVS LPKSPKMVQP RRDGYFEGIE EDPIHKDTTA NEKLERNREY TYQWLHTQVG VHETTSSRNM KCNHFLPELD PDVLNGGRVQ LVARLVSRED TDLDLFSMTN GSALSVNREK KNQAHRHSAG SSSKLWFPSK LI
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