About PiggyBac transposable element-derived protein 1
PiggyBac transposable element-derived protein 1 (PGBD1) is a protein
from Homo sapiens identified by UniProt accession
Q96JS3, 809 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Target properties
| Protein name | PiggyBac transposable element-derived protein 1 |
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| UniProt accession | Q96JS3 |
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| Gene | PGBD1 |
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| Organism | Homo sapiens |
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| Length | 809 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (124)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.33
- pulse pressure measurement · score 0.30
- psoriasis · score 0.27
- eosinophil count · score 0.26
- mucocutaneous lymph node syndrome · score 0.25
- sleep duration · score 0.23
- mean reticulocyte volume · score 0.19
- urate measurement · score 0.19
- low density lipoprotein cholesterol measurement · score 0.16
- MHC class I polypeptide-related sequence B measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96JS3-F1 | alphafold | PREDICTED | 65.84 | — |
Amino-acid sequence (809 residues)
MYEALPGPAP ENEDGLVKVK EEDPTWEQVC NSQEGSSHTQ EICRLRFRHF CYQEAHGPQE ALAQLRELCH QWLRPEMHTK EQIMELLVLE QFLTILPKEL QPCVKTYPLE SGEEAVTVLE NLETGSGDTG QQASVYIQGQ DMHPMVAEYQ GVSLECQSLQ LLPGITTLKC EPPQRPQGNP QEVSGPVPHG SAHLQEKNPR DKAVVPVFNP VRSQTLVKTE EETAQAVAAE KWSHLSLTRR NLCGNSAQET VMSLSPMTEE IVTKDRLFKA KQETSEEMEQ SGEASGKPNR ECAPQIPCST PIATERTVAH LNTLKDRHPG DLWARMHISS LEYAAGDITR KGRKKDKARV SELLQGLSFS GDSDVEKDNE PEIQPAQKKL KVSCFPEKSW TKRDIKPNFP SWSALDSGLL NLKSEKLNPV ELFELFFDDE TFNLIVNETN NYASQKNVSL EVTVQEMRCV FGVLLLSGFM RHPRREMYWE VSDTDQNLVR DAIRRDRFEL IFSNLHFADN GHLDQKDKFT KLRPLIKQMN KNFLLYAPLE EYYCFDKSMC ECFDSDQFLN GKPIRIGYKI WCGTTTQGYL VWFEPYQEES TMKVDEDPDL GLGGNLVMNF ADVLLERGQY PYHLCFDSFF TSVKLLSALK KKGVRATGTI RENRTEKCPL MNVEHMKKMK RGYFDFRIEE NNEIILCRWY GDGIISLCSN AVGIEPVNEV SCCDADNEEI PQISQPSIVK VYDECKEGVA KMDQIISKYR VRIRSKKWYS ILVSYMIDVA MNNAWQLHRA CNPGASLDPL DFRRFVAHFY LEHNAHLSD
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