Hematopoietic SH2 domain-containing protein (HSH2D)

About Hematopoietic SH2 domain-containing protein

Hematopoietic SH2 domain-containing protein (HSH2D) is a protein from Homo sapiens identified by UniProt accession Q96JZ2, 352 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Hematopoietic SH2 domain-containing protein
UniProt accession	Q96JZ2
Gene	HSH2D
Organism	Homo sapiens
Length	352 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.34
mean corpuscular hemoglobin concentration · score 0.30
mean corpuscular hemoglobin · score 0.24
mean platelet volume · score 0.14
myeloperoxidase measurement · score 0.13
Red cell distribution width · score 0.12
generalized anxiety disorder · score 0.11
acute lymphoblastic leukemia · score 0.07
age at onset · score 0.06
Myopia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96JZ2-F1	alphafold	PREDICTED	62.23	—

Amino-acid sequence (352 residues)

MTEAGKLPLP LPPRLDWFVH TQMGQLAQDG VPEWFHGAIS REDAENLLES QPLGSFLIRV SHSHVGYTLS YKAQSSCCHF MVKLLDDGTF MIPGEKVAHT SLDALVTFHQ QKPIEPRREL LTQPCRQKDP ANVDYEDLFL YSNAVAEEAA CPVSAPEEAS PKPVLCHQSK ERKPSAEMNR ITTKEATSSC PPKSPLGETR QKLWRSLKML PERGQRVRQQ LKSHLATVNL SSLLDVRRST VISGPGTGKG SQDHSGDPTS GDRGYTDPCV ATSLKSPSQP QAPKDRKVPT RKAERSVSCI EVTPGDRSWH QMVVRALSSQ ESKPEHQGLA EPENDQLPEE YQQPPPFAPG YC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards