Fatty acyl-CoA reductase 2 (FAR2)

About Fatty acyl-CoA reductase 2

Fatty acyl-CoA reductase 2 (FAR2) is a protein from Homo sapiens identified by UniProt accession Q96K12, 515 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	Fatty acyl-CoA reductase 2
UniProt accession	Q96K12
Gene	FAR2
Organism	Homo sapiens
Length	515 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

platelet count · score 0.42
mean platelet volume · score 0.40
hair shape measurement · score 0.37
platelet component distribution width · score 0.36
breast carcinoma · score 0.34
balding measurement · score 0.33
androgenetic alopecia · score 0.29
heel bone mineral density · score 0.28
alopecia · score 0.27
platelet-to-lymphocyte ratio · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96K12-F1	alphafold	PREDICTED	94.14	—

Amino-acid sequence (515 residues)

MSTIAAFYGG KSILITGATG FLGKVLMEKL FRTSPDLKVI YILVRPKAGQ TLQQRVFQIL DSKLFEKVKE VCPNVHEKIR AIYADLNQND FAISKEDMQE LLSCTNIIFH CAATVRFDDT LRHAVQLNVT ATRQLLLMAS QMPKLEAFIH ISTAYSNCNL KHIDEVIYPC PVEPKKIIDS LEWLDDAIID EITPKLIRDW PNIYTYTKAL GEMVVQQESR NLNIAIIRPS IVGATWQEPF PGWVDNINGP NGIIIATGKG FLRAIKATPM AVADVIPVDT VVNLMLAVGW YTAVHRPKST LVYHITSGNM NPCNWHKMGV QVLATFEKIP FERPFRRPNA NFTSNSFTSQ YWNAVSHRAP AIIYDCYLRL TGRKPRMTKL MNRLLRTVSM LEYFINRSWE WSTYNTEMLM SELSPEDQRV FNFDVRQLNW LEYIENYVLG VKKYLLKEDM AGIPKAKQRL KRLRNIHYLF NTALFLIAWR LLIARSQMAR NVWFFIVSFC YKFLSYFRAS STLKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards