About E3 ubiquitin-protein ligase RNF170
E3 ubiquitin-protein ligase RNF170 (RNF170) is a protein
from Homo sapiens identified by UniProt accession
Q96K19, 258 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF170 |
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| UniProt accession | Q96K19 |
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| Gene | RNF170 |
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| Organism | Homo sapiens |
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| Length | 258 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- spastic paraplegia 85, autosomal recessive · score 0.65
- autosomal dominant sensory ataxia 1 · score 0.62
- Spastic paraplegia · score 0.42
- neurodegenerative disease · score 0.37
- Neurodevelopmental disorder · score 0.34
- genetic disorder · score 0.18
- hereditary spastic paraplegia · score 0.05
- abscess · score 0.04
- body height · score 0.03
- infection · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96K19-F1 | alphafold | PREDICTED | 78.00 | — |
Amino-acid sequence (258 residues)
MAKYQGEVQS LKLDDDSVIE GVSDQVLVAV VVSFALIATL VYALFRNVHQ NIHPENQELV RVLREQLQTE QDAPAATRQQ FYTDMYCPIC LHQASFPVET NCGHLFCGAC IIAYWRYGSW LGAISCPICR QTVTLLLTVF GEDDQSQDVL RLHQDINDYN RRFSGQPRSI MERIMDLPTL LRHAFREMFS VGGLFWMFRI RIILCLMGAF FYLISPLDFV PEALFGILGF LDDFFVIFLL LIYISIMYRE VITQRLTR
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