About Transmembrane protein 87B
Transmembrane protein 87B (TMEM87B) is a protein
from Homo sapiens identified by UniProt accession
Q96K49, 555 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Transmembrane protein 87B |
|---|
| UniProt accession | Q96K49 |
|---|
| Gene | TMEM87B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 555 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (50)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.40
- type 2 diabetes mellitus · score 0.36
- Varicose veins · score 0.28
- systolic blood pressure · score 0.28
- neurodegenerative disease · score 0.24
- body fat percentage · score 0.23
- neutrophil percentage of leukocytes · score 0.20
- leukocyte count · score 0.16
- blood protein measurement · score 0.15
- aspartate aminotransferase measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96K49-F1 | alphafold | PREDICTED | 73.92 | — |
Amino-acid sequence (555 residues)
MVAACRSVAG LLPRRRRCFP ARAPLLRVAL CLLCWTPAAV RAVPELGLWL ETVNDKSGPL IFRKTMFNST DIKLSVKSFH CSGPVKFTIV WHLKYHTCHN EHSNLEELFQ KHKLSVDEDF CHYLKNDNCW TTKNENLDCN SDSQVFPSLN NKELINIRNV SNQERSMDVV ARTQKDGFHI FIVSIKTENT DASWNLNVSL SMIGPHGYIS ASDWPLMIFY MVMCIVYILY GILWLTWSAC YWKDILRIQF WIAAVIFLGM LEKAVFYSEY QNISNTGLST QGLLIFAELI SAIKRTLARL LVIIVSLGYG IVKPRLGTVM HRVIGLGLLY LIFAAVEGVM RVIGGSNHLA VVLDDIILAV IDSIFVWFIF ISLAQTMKTL RLRKNTVKFS LYRHFKNTLI FAVLASIVFM GWTTKTFRIA KCQSDWMERW VDDAFWSFLF SLILIVIMFL WRPSANNQRY AFMPLIDDSD DEIEEFMVTS ENLTEGIKLR ASKSVSNGTA KPATSENFDE DLKWVEENIP SSFTDVALPV LVDSDEEIMT RSEMAEKMFS SEKIM
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