About Zinc finger protein 668
Zinc finger protein 668 (ZNF668) is a protein
from Homo sapiens identified by UniProt accession
Q96K58, 619 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Zinc finger protein 668 |
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| UniProt accession | Q96K58 |
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| Gene | ZNF668 |
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| Organism | Homo sapiens |
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| Length | 619 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (75)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with poor growth, large ears, and dysmorphic facies · score 0.53
- Profound global developmental delay · score 0.42
- Failure to thrive · score 0.42
- Severe short-limb dwarfism · score 0.33
- neurodegenerative disease · score 0.27
- Microcephaly · score 0.23
- Growth delay · score 0.23
- Abnormal facial shape · score 0.23
- cerebral malformation · score 0.23
- Severe global developmental delay · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96K58-F1 | alphafold | PREDICTED | 71.07 | — |
Amino-acid sequence (619 residues)
MEVEAAEARS PAPGYKRSGR RYKCLSCTKT FPNAPRAARH AATHGPADCS EEVAEVKPKP ETEAKAEEAS GEKVSGSAAK PRPYACPLCP KAYKTAPELR SHGRSHTGEK PFPCPECGRR FMQPVCLRVH LASHAGELPF RCAHCPKAYG ALSKLKIHQR GHTGERPYAC ADCGKSFADP SVFRKHRRTH AGLRPYSCER CGKAYAELKD LRNHERSHTG ERPFLCSECG KSFSRSSSLT CHQRIHAAQK PYRCPACGKG FTQLSSYQSH ERTHSGEKPF LCPRCGRMFS DPSSFRRHQR AHEGVKPYHC EKCGKDFRQP ADLAMHRRVH TGDRPFKCLQ CDKTFVASWD LKRHALVHSG QRPFRCEECG RAFAERASLT KHSRVHSGER PFHCNACGKS FVVSSSLRKH ERTHRSSEAA GVPPAQELVV GLALPVGVAG ESSAAPAAGA GLGDPPAGLL GLPPESGGVM ATQWQVVGMT VEHVECQDAG VREAPGPLEG AGEAGGEEAD EKPPQFVCRE CKETFSTMTL LRRHERSHPE LRPFPCTQCG KSFSDRAGLR KHSRTHSSVR PYTCPHCPKA FLSASDLRKH ERTHPVPMGT PTPLEPLVAL LGMPEEGPA
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