About Zinc finger and BTB domain-containing protein 45
Zinc finger and BTB domain-containing protein 45 (ZBTB45) is a protein
from Homo sapiens identified by UniProt accession
Q96K62, 511 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 45 |
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| UniProt accession | Q96K62 |
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| Gene | ZBTB45 |
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| Organism | Homo sapiens |
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| Length | 511 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (33)
Diseases linked to this target (Open Targets).
- body height · score 0.26
- sex hormone-binding globulin measurement · score 0.18
- mathematical ability · score 0.18
- forced expiratory volume · score 0.13
- mean platelet volume · score 0.09
- low density lipoprotein cholesterol measurement · score 0.09
- colorectal cancer · score 0.08
- colorectal adenoma · score 0.08
- mean corpuscular hemoglobin concentration · score 0.08
- platelet count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96K62-F1 | alphafold | PREDICTED | 62.19 | — |
Amino-acid sequence (511 residues)
MAAAEAVHHI HLQNFSRSLL ETLNGQRLGG HFCDVTVRIR EASLRAHRCV LAAGSPFFQD KLLLGHSEIR VPPVVPAQTV RQLVEFLYSG SLVVAQGEAL QVLTAASVLR IQTVIDECTQ IIARARAPGT SAPTPLPTPV PPPLAPAQLR HRLRHLLAAR PPGHPGAAHS RKQRQPARLQ LPAPPTPAKA EGPDADPSLS AAPDDRGDED DEESDDETDG EDGEGGGPGE GQAPPSFPDC AAGFLTAAAD SACEEPPAPT GLADYSGAGR DFLRGAGSAE DVFPDSYVST WHDEDGAVPE GCPTETPVQP DCILSGSRPP GVKTPGPPVA LFPFHLGAPG PPAPPPSAPS GPAPAPPPAF YPTLQPEAAP STQLGEVPAP SAAPTTAPSG TPARTPGAEP PTYECSHCRK TFSSRKNYTK HMFIHSGEKP HQCAVCWRSF SLRDYLLKHM VTHTGVRAFQ CAVCAKRFTQ KSSLNVHMRT HRPERAPCPA CGKVFSHRAL LERHLAAHPA P
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