About Adhesion G-protein coupled receptor G7
Adhesion G-protein coupled receptor G7 (ADGRG7) is a protein
from Homo sapiens identified by UniProt accession
Q96K78, 797 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Adhesion G-protein coupled receptor G7 |
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| UniProt accession | Q96K78 |
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| Gene | ADGRG7 |
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| Organism | Homo sapiens |
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| Length | 797 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.19
- self reported educational attainment · score 0.09
- X-linked retinal dysplasia · score 0.05
- snowflake vitreoretinal degeneration · score 0.04
- Familial exudative vitreoretinopathy · score 0.04
- retinitis pigmentosa · score 0.04
- cataract 50 with or without glaucoma · score 0.04
- Rare isolated myopia · score 0.04
- isolated ectopia lentis · score 0.04
- congenital short bowel syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96K78-F1 | alphafold | PREDICTED | 80.45 | — |
Amino-acid sequence (797 residues)
MASCRAWNLR VLVAVVCGLL TGIILGLGIW RIVIRIQRGK STSSSSTPTE FCRNGGTWEN GRCICTEEWK GLRCTIANFC ENSTYMGFTF ARIPVGRYGP SLQTCGKDTP NAGNPMAVRL CSLSLYGEIE LQKVTIGNCN ENLETLEKQV KDVTAPLNNI SSEVQILTSD ANKLTAENIT SATRVVGQIF NTSRNASPEA KKVAIVTVSQ LLDASEDAFQ RVAATANDDA LTTLIEQMET YSLSLGNQSV VEPNIAIQSA NFSSENAVGP SNVRFSVQKG ASSSLVSSST FIHTNVDGLN PDAQTELQVL LNMTKNYTKT CGFVVYQNDK LFQSKTFTAK SDFSQKIISS KTDENEQDQS ASVDMVFSPK YNQKEFQLYS YACVYWNLSA KDWDTYGCQK DKGTDGFLRC RCNHTTNFAV LMTFKKDYQY PKSLDILSNV GCALSVTGLA LTVIFQIVTR KVRKTSVTWV LVNLCISMLI FNLLFVFGIE NSNKNLQTSD GDINNIDFDN NDIPRTDTIN IPNPMCTAIA ALLHYFLLVT FTWNALSAAQ LYYLLIRTMK PLPRHFILFI SLIGWGVPAI VVAITVGVIY SQNGNNPQWE LDYRQEKICW LAIPEPNGVI KSPLLWSFIV PVTIILISNV VMFITISIKV LWKNNQNLTS TKKVSSMKKI VSTLSVAVVF GITWILAYLM LVNDDSIRIV FSYIFCLFNT TQGLQIFILY TVRTKVFQSE ASKVLMLLSS IGRRKSLPSV TRPRLRVKMY NFLRSLPTLH ERFRLLETSP STEEITLSES DNAKESI
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