About Calcium-binding and spermatid-specific protein 1
Calcium-binding and spermatid-specific protein 1 (CABS1) is a protein
from Homo sapiens identified by UniProt accession
Q96KC9, 395 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Calcium-binding and spermatid-specific protein 1 |
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| UniProt accession | Q96KC9 |
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| Gene | CABS1 |
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| Organism | Homo sapiens |
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| Length | 395 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (68)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 27 · score 0.07
- spermatogenic failure 18 · score 0.07
- spermatogenic failure 46 · score 0.07
- spermatogenic failure 43 · score 0.07
- spermatogenic failure 19 · score 0.07
- spermatogenic failure 45 · score 0.07
- spermatogenic failure 49 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96KC9-F1 | alphafold | PREDICTED | 39.88 | — |
Amino-acid sequence (395 residues)
MAEDGLPKIY SHPPTESSKT PTAATIFFGA DNAIPKSETT ITSEGDHVTS VNEYMLESDF STTTDNKLTA KKEKLKSEDD MGTDFIKSTT HLQKEITSLT GTTNSITRDS ITEHFMPVKI GNISSPVTTV SLIDFSTDIA KEDILLATID TGDAEISITS EVSGTLKDSS AGVADAPAFP RKKDEADMSN YNSSIKSNVP ADEAVQVTDS TIPEAEIPPA PEESFTTIPD ITALEEEKIT EIDLSVLEDD TSAVATLTDS DEKFITVFEL TTSAEKDKDK REDTLLTDEE TTEGASIWME RDTANEAETH SVLLTAVESR YDFVVPASIA TNLVEESSTE EDLSETDNTE TVPKITEPFS GTTSVLDTPD YKEDTSTTET DIFELLKEEP DEFMI
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