Golgi-associated RAB2 interactor protein 1B (GARIN1B)

About Golgi-associated RAB2 interactor protein 1B

Golgi-associated RAB2 interactor protein 1B (GARIN1B) is a protein from Homo sapiens identified by UniProt accession Q96KD3, 344 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Golgi-associated RAB2 interactor protein 1B
UniProt accession	Q96KD3
Gene	GARIN1B
Organism	Homo sapiens
Length	344 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

atrial fibrillation · score 0.17
atrial flutter · score 0.17
azoospermia · score 0.10
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.07
spermatogenic failure 72 · score 0.07
spermatogenic failure 27 · score 0.07
spermatogenic failure 46 · score 0.07
spermatogenic failure 18 · score 0.07
spermatogenic failure 49 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96KD3-F1	alphafold	PREDICTED	61.93	—

Amino-acid sequence (344 residues)

MLSSFPHRKT WRKSKKTVKV TRSYPTFPSL NAWEEFRGLL PVDGEPNPGA GLGVEEGLLC RVVHSPEFNL FLDSVVFESN FIQVKRGRNW RDVYKASNTM ALGVTSSVPC LPLPNILLMA SVKWHQGQNQ TWNRPSIAPN IFLKRILPLR FVELQVCDHY QRILQLRTVT EKIYYLKLHP DHPETVFHFW IRLVQILQKG LSITTKDPRI LVTHCLVPKN CSSPSGDSKL VQKKLQASQP SESLIQLMTK GESEALSQIF ADLHQQNQLS FRSSRKVETN KNSSGKDSSR EDSIPCTCDL RWRASFTYGE WERENPSGLQ PLSLLSTLAA STGPQLAPPI GNSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards