Small integral membrane protein 8 (SMIM8)

About Small integral membrane protein 8

Small integral membrane protein 8 (SMIM8) is a protein from Homo sapiens identified by UniProt accession Q96KF7, 97 residues long. MolForge cross-references it against 0 known binders and 30 disease associations.

Target properties

Protein name	Small integral membrane protein 8
UniProt accession	Q96KF7
Gene	SMIM8
Organism	Homo sapiens
Length	97 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (30)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.24
eosinophil percentage of leukocytes · score 0.21
IGF-1 measurement · score 0.18
physical activity · score 0.16
leukocyte count · score 0.15
atrial fibrillation · score 0.14
body height · score 0.13
lymphocyte percentage of leukocytes · score 0.13
eosinophil percentage of granulocytes · score 0.11
neutrophil percentage of granulocytes · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96KF7-F1	alphafold	PREDICTED	66.60	—

Amino-acid sequence (97 residues)

MSSAPEPPTF KKEPPKEKEF QSPGLRGVRT TTLFRAVNPE LFIKPNKPVM AFGLVTLSLC VAYIGYLHAI QENKKDLYEA IDSEGHSYMR RKTSKWD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards