Homeobox protein PKNOX2 (PKNOX2)

About Homeobox protein PKNOX2

Homeobox protein PKNOX2 (PKNOX2) is a protein from Homo sapiens identified by UniProt accession Q96KN3, 472 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	Homeobox protein PKNOX2
UniProt accession	Q96KN3
Gene	PKNOX2
Organism	Homo sapiens
Length	472 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

testosterone measurement · score 0.43
heel bone mineral density · score 0.42
vital capacity · score 0.32
Testicular Germ Cell Tumor · score 0.32
prostate carcinoma · score 0.31
autosomal dominant compelling helio-ophthalmic outburst syndrome · score 0.30
neurodegenerative disease · score 0.29
brain measurement · score 0.26
aspartate aminotransferase measurement · score 0.18
survival time · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96KN3-F1	alphafold	PREDICTED	60.16	—

Amino-acid sequence (472 residues)

MMQHASPAPA LTMMATQNVP PPPYQDSPQM TATAQPPSKA QAVHISAPSA AASTPVPSAP IDPQAQLEAD KRAVYRHPLF PLLTLLFEKC EQATQGSECI TSASFDVDIE NFVHQQEQEH KPFFSDDPEL DNLMVKAIQV LRIHLLELEK VNELCKDFCN RYITCLKTKM HSDNLLRNDL GGPYSPNQPS INLHSQDLLQ NSPNSMSGVS NNPQGIVVPA SALQQGNIAM TTVNSQVVSG GALYQPVTMV TSQGQVVTQA IPQGAIQIQN TQVNLDLTSL LDNEDKKSKN KRGVLPKHAT NIMRSWLFQH LMHPYPTEDE KRQIAAQTNL TLLQVNNWFI NARRRILQPM LDASNPDPAP KAKKIKSQHR PTQRFWPNSI AAGVLQQQGG APGTNPDGSI NLDNLQSLSS DSATMAMQQA MMAAHDDSLD GTEEEDEDEM EEEEEEELEE EVDELQTTNV SDLGLEHSDS LE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards