F-actin-capping protein subunit alpha-3 (CAPZA3)

About F-actin-capping protein subunit alpha-3

F-actin-capping protein subunit alpha-3 (CAPZA3) is a protein from Homo sapiens identified by UniProt accession Q96KX2, 299 residues long. MolForge cross-references it against 0 known binders and 97 disease associations.

Target properties

Protein name	F-actin-capping protein subunit alpha-3
UniProt accession	Q96KX2
Gene	CAPZA3
Organism	Homo sapiens
Length	299 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

mitochondrial DNA measurement · score 0.12
azoospermia · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.08
spermatogenic failure 65 · score 0.07
spermatogenic failure 56 · score 0.07
spermatogenic failure, X-linked, 3 · score 0.07
spermatogenic failure 40 · score 0.07
spermatogenic failure 10 · score 0.07
spermatogenic failure 11 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96KX2-F1	alphafold	PREDICTED	88.95	—

Amino-acid sequence (299 residues)

MTLSVLSRKD KERVIRRLLL QAPPGEFVNA FDDLCLLIRD EKLMHHQGEC AGHQHCQKYS VPLCIDGNPV LLSHHNVMGD YRFFDHQSKL SFKYDLLQNQ LKDIQSHGII QNEAEYLRVV LLCALKLYVN DHYPKGNCNM LRKTVKSKEY LIACIEDHNY ETGECWNGLW KSKWIFQVNP FLTQVTGRIF VQAHFFRCVN LHIEISKDLK ESLEIVNQAQ LALSFARLVE EQENKFQAAV LEELQELSNE ALRKILRRDL PVTRTLIDWH RILSDLNLVM YPKLGYVIYS RSVLCNWII

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards