Calreticulin-3 (CALR3)

About Calreticulin-3

Calreticulin-3 (CALR3) is a protein from Homo sapiens identified by UniProt accession Q96L12, 384 residues long. MolForge cross-references it against 0 known binders and 107 disease associations.

Target properties

Protein name	Calreticulin-3
UniProt accession	Q96L12
Gene	CALR3
Organism	Homo sapiens
Length	384 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (107)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.30
leukocyte count · score 0.27
Rare familial disorder with hypertrophic cardiomyopathy · score 0.21
hypertrophic cardiomyopathy 19 · score 0.21
hypertrophic cardiomyopathy · score 0.17
Abnormality of the cardiovascular system · score 0.15
cardiomyopathy · score 0.13
restrictive cardiomyopathy · score 0.12
dilated cardiomyopathy · score 0.11
familial hypertrophic cardiomyopathy · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96L12-F1	alphafold	PREDICTED	77.67	—

Amino-acid sequence (384 residues)

MARALVQLWA ICMLRVALAT VYFQEEFLDG EHWRNRWLQS TNDSRFGHFR LSSGKFYGHK EKDKGLQTTQ NGRFYAISAR FKPFSNKGKT LVIQYTVKHE QKMDCGGGYI KVFPADIDQK NLNGKSQYYI MFGPDICGFD IKKVHVILHF KNKYHENKKL IRCKVDGFTH LYTLILRPDL SYDVKIDGQS IESGSIEYDW NLTSLKKETS PAESKDWEQT KDNKAQDWEK HFLDASTSKQ SDWNGDLDGD WPAPMLQKPP YQDGLKPEGI HKDVWLHRKM KNTDYLTQYD LSEFENIGAI GLELWQVRSG TIFDNFLITD DEEYADNFGK ATWGETKGPE REMDAIQAKE EMKKAREEEE EELLSGKINR HEHYFNQFHR RNEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards