About Rho-related GTP-binding protein RhoV
Rho-related GTP-binding protein RhoV (RHOV) is a protein
from Homo sapiens identified by UniProt accession
Q96L33, 236 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | Rho-related GTP-binding protein RhoV |
|---|
| UniProt accession | Q96L33 |
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| Gene | RHOV |
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| Organism | Homo sapiens |
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| Length | 236 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- lysosomal storage disease · score 0.27
- Parkinson disease · score 0.27
- multiple sclerosis · score 0.27
- Alzheimer disease · score 0.27
- neurodegenerative disease · score 0.27
- lung adenocarcinoma · score 0.10
- neoplasm · score 0.08
- Zika virus infectious disease · score 0.07
- non-small cell lung carcinoma · score 0.07
- cancer · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96L33-F1 | alphafold | PREDICTED | 86.56 | — |
Amino-acid sequence (236 residues)
MPPRELSEAE PPPLRAPTPP PRRRSAPPEL GIKCVLVGDG AVGKSSLIVS YTCNGYPARY RPTALDTFSV QVLVDGAPVR IELWDTAGQE DFDRLRSLCY PDTDVFLACF SVVQPSSFQN ITEKWLPEIR THNPQAPVLL VGTQADLRDD VNVLIQLDQG GREGPVPQPQ AQGLAEKIRA CCYLECSALT QKNLKEVFDS AILSAIEHKA RLEKKLNAKG VRTLSRCRWK KFFCFV
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