About Calpain small subunit 2
Calpain small subunit 2 (CAPNS2) is a protein
from Homo sapiens identified by UniProt accession
Q96L46, 248 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Calpain small subunit 2 |
|---|
| UniProt accession | Q96L46 |
|---|
| Gene | CAPNS2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 248 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.37
- tuberculosis · score 0.08
- thyroxine measurement · score 0.06
- hormone measurement · score 0.06
- heel bone mineral density · score 0.05
- bone quantitative ultrasound measurement · score 0.04
- non-small cell lung carcinoma · score 0.04
- esophageal adenocarcinoma · score 0.04
- Barrett's esophagus · score 0.04
- bone density · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96L46-F1 | alphafold | PREDICTED | 75.34 | — |
Amino-acid sequence (248 residues)
MFLAKALLEG ADRGLGEALG GLFGGGGQRR EGGGRNIGGI VGGIVNFISE AAAAQYTPEP PPTQQHFTSV EASESEEVRR FRQQFTQLAG PDMEVGATDL MNILNKVLSK HKDLKTDGFS LDTCRSIVSV MDSDTTGKLG FEEFKYLWNN IKKWQCVYKQ YDRDHSGSLG SSQLRGALQA AGFQLNEQLY QMIVRRYANE DGDMDFNNFI SCLVRLDAMF RAFKSLDRDR DGLIQVSIKE WLQLTMYS
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