Leucine-rich repeat protein 1 (LRR1)

About Leucine-rich repeat protein 1

Leucine-rich repeat protein 1 (LRR1) is a protein from Homo sapiens identified by UniProt accession Q96L50, 414 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.

Target properties

Protein name	Leucine-rich repeat protein 1
UniProt accession	Q96L50
Gene	LRR1
Organism	Homo sapiens
Length	414 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (90)

Diseases linked to this target (Open Targets).

mathematical ability · score 0.26
neurodegenerative disease · score 0.20
self reported educational attainment · score 0.18
blood protein measurement · score 0.18
esophageal squamous cell carcinoma · score 0.15
neuroblastoma · score 0.15
Ewing sarcoma · score 0.15
C-reactive protein measurement · score 0.14
fatty acid measurement · score 0.14
eicosadienoic acid measurement · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96L50-F1	alphafold	PREDICTED	88.20	—

Amino-acid sequence (414 residues)

MKLHCEVEVI SRHLPALGLR NRGKGVRAVL SLCQQTSRSQ PPVRAFLLIS TLKDKRGTRY ELRENIEQFF TKFVDEGKAT VRLKEPPVDI CLSKAISSSL KGFLSAMRLA HRGCNVDTPV STLTPVKTSE FENFKTKMVI TSKKDYPLSK NFPYSLEHLQ TSYCGLVRVD MRMLCLKSLR KLDLSHNHIK KLPATIGDLI HLQELNLNDN HLESFSVALC HSTLQKSLRS LDLSKNKIKA LPVQFCQLQE LKNLKLDDNE LIQFPCKIGQ LINLRFLSAA RNKLPFLPSE FRNLSLEYLD LFGNTFEQPK VLPVIKLQAP LTLLESSART ILHNRIPYGS HIIPFHLCQD LDTAKICVCG RFCLNSFIQG TTTMNLHSVA HTVVLVDNLG GTEAPIISYF CSLGCYVNSS DMLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards