Beta-1,3-galactosyltransferase 6 (B3GALT6)

About Beta-1,3-galactosyltransferase 6

Beta-1,3-galactosyltransferase 6 (B3GALT6) is a protein from Homo sapiens identified by UniProt accession Q96L58, 329 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Beta-1,3-galactosyltransferase 6
UniProt accession	Q96L58
Gene	B3GALT6
Organism	Homo sapiens
Length	329 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures · score 0.83
Ehlers-Danlos syndrome, spondylodysplastic type, 2 · score 0.79
Ehlers-Danlos syndrome, progeroid type · score 0.72
Al-Gazali syndrome · score 0.60
Ehlers-Danlos syndrome · score 0.56
spondyloepimetaphyseal dysplasia with joint laxity · score 0.53
Spondyloepiphyseal dysplasia and spondyloepimetaphyseal dysplasia · score 0.37
spondyloepiphyseal dysplasia · score 0.27
genetic disorder · score 0.19
Crohn's disease · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96L58-F1	alphafold	PREDICTED	90.62	—

Amino-acid sequence (329 residues)

MKLLRRAWRR RAALGLGTLA LCGAALLYLA RCAAEPGDPR AMSGRSPPPP APARAAAFLA VLVASAPRAA ERRSVIRSTW LARRGAPGDV WARFAVGTAG LGAEERRALE REQARHGDLL LLPALRDAYE NLTAKVLAML AWLDEHVAFE FVLKADDDSF ARLDALLAEL RAREPARRRR LYWGFFSGRG RVKPGGRWRE AAWQLCDYYL PYALGGGYVL SADLVHYLRL SRDYLRAWHS EDVSLGAWLA PVDVQREHDP RFDTEYRSRG CSNQYLVTHK QSLEDMLEKH ATLAREGRLC KREVQLRLSY VYDWSAPPSQ CCQRREGIP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards