Sorting nexin-27 (SNX27)

About Sorting nexin-27

Sorting nexin-27 (SNX27) is a protein from Homo sapiens identified by UniProt accession Q96L92, 541 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	Sorting nexin-27
UniProt accession	Q96L92
Gene	SNX27
Organism	Homo sapiens
Length	541 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

Dravet syndrome · score 0.55
Global developmental delay · score 0.42
Intellectual disability · score 0.42
Generalized hypotonia · score 0.42
Seizure · score 0.42
leukocyte count · score 0.22
neutrophil count · score 0.22
genetic disorder · score 0.19
granulocyte count · score 0.17
Blackfan-Diamond anemia · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96L92-F1	alphafold	PREDICTED	83.63	—

Amino-acid sequence (541 residues)

MADEDGEGIH PSAPHRNGGG GGGGGSGLHC AGNGGGGGGG PRVVRIVKSE SGYGFNVRGQ VSEGGQLRSI NGELYAPLQH VSAVLPGGAA DRAGVRKGDR ILEVNHVNVE GATHKQVVDL IRAGEKELIL TVLSVPPHEA DNLDPSDDSL GQSFYDYTEK QAVPISVPRY KHVEQNGEKF VVYNVYMAGR QLCSKRYREF AILHQNLKRE FANFTFPRLP GKWPFSLSEQ QLDARRRGLE EYLEKVCSIR VIGESDIMQE FLSESDENYN GVSDVELRVA LPDGTTVTVR VKKNSTTDQV YQAIAAKVGM DSTTVNYFAL FEVISHSFVR KLAPNEFPHK LYIQNYTSAV PGTCLTIRKW LFTTEEEILL NDNDLAVTYF FHQAVDDVKK GYIKAEEKSY QLQKLYEQRK MVMYLNMLRT CEGYNEIIFP HCACDSRRKG HVITAISITH FKLHACTEEG QLENQVIAFE WDEMQRWDTD EEGMAFCFEY ARGEKKPRWV KIFTPYFNYM HECFERVFCE LKWRKENIFQ MARSQQRDVA T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards