Fc receptor-like protein 2 (FCRL2)

About Fc receptor-like protein 2

Fc receptor-like protein 2 (FCRL2) is a protein from Homo sapiens identified by UniProt accession Q96LA5, 508 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Fc receptor-like protein 2
UniProt accession	Q96LA5
Gene	FCRL2
Organism	Homo sapiens
Length	508 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.33
neurodegenerative disease · score 0.31
Alzheimer disease · score 0.31
Parkinson disease · score 0.31
lysosomal storage disease · score 0.31
blood protein measurement · score 0.23
coronary artery disease · score 0.16
neuroinflammatory disorder · score 0.14
Graves disease · score 0.10
systemic lupus erythematosus · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96LA5-F1	alphafold	PREDICTED	80.72	—

Amino-acid sequence (508 residues)

MLLWSLLVIF DAVTEQADSL TLVAPSSVFE GDSIVLKCQG EQNWKIQKMA YHKDNKELSV FKKFSDFLIQ SAVLSDSGNY FCSTKGQLFL WDKTSNIVKI KVQELFQRPV LTASSFQPIE GGPVSLKCET RLSPQRLDVQ LQFCFFRENQ VLGSGWSSSP ELQISAVWSE DTGSYWCKAE TVTHRIRKQS LQSQIHVQRI PISNVSLEIR APGGQVTEGQ KLILLCSVAG GTGNVTFSWY REATGTSMGK KTQRSLSAEL EIPAVKESDA GKYYCRADNG HVPIQSKVVN IPVRIPVSRP VLTLRSPGAQ AAVGDLLELH CEALRGSPPI LYQFYHEDVT LGNSSAPSGG GASFNLSLTA EHSGNYSCEA NNGLGAQCSE AVPVSISGPD GYRRDLMTAG VLWGLFGVLG FTGVALLLYA LFHKISGESS ATNEPRGASR PNPQEFTYSS PTPDMEELQP VYVNVGSVDV DVVYSQVWSM QQPESSANIR TLLENKDSQV IYSSVKKS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards