Protein arginine N-methyltransferase 6 (PRMT6)

About Protein arginine N-methyltransferase 6

Protein arginine N-methyltransferase 6 (PRMT6) is a protein from Homo sapiens identified by UniProt accession Q96LA8, 375 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	Protein arginine N-methyltransferase 6
UniProt accession	Q96LA8
Gene	PRMT6
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.46
testosterone measurement · score 0.43
bilirubin measurement · score 0.42
serum gamma-glutamyl transferase measurement · score 0.42
lean body mass · score 0.42
Red cell distribution width · score 0.41
body fat percentage · score 0.41
low density lipoprotein cholesterol measurement · score 0.40
body mass index · score 0.40
cystatin C measurement · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96LA8-F1	alphafold	PREDICTED	93.45	—

Amino-acid sequence (375 residues)

MSQPKKRKLE SGGGGEGGEG TEEEDGAERE AALERPRRTK RERDQLYYEC YSDVSVHEEM IADRVRTDAY RLGILRNWAA LRGKTVLDVG AGTGILSIFC AQAGARRVYA VEASAIWQQA REVVRFNGLE DRVHVLPGPV ETVELPEQVD AIVSEWMGYG LLHESMLSSV LHARTKWLKE GGLLLPASAE LFIAPISDQM LEWRLGFWSQ VKQHYGVDMS CLEGFATRCL MGHSEIVVQG LSGEDVLARP QRFAQLELSR AGLEQELEAG VGGRFRCSCY GSAPMHGFAI WFQVTFPGGE SEKPLVLSTS PFHPATHWKQ ALLYLNEPVQ VEQDTDVSGE ITLLPSRDNP RRLRVLLRYK VGDQEEKTKD FAMED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards