About Intraflagellar transport protein 74 homolog
Intraflagellar transport protein 74 homolog (IFT74) is a protein
from Homo sapiens identified by UniProt accession
Q96LB3, 600 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Intraflagellar transport protein 74 homolog |
|---|
| UniProt accession | Q96LB3 |
|---|
| Gene | IFT74 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 600 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- Joubert syndrome 40 · score 0.72
- Bardet-Biedl syndrome · score 0.57
- genetic disorder · score 0.41
- Joubert syndrome · score 0.37
- Male infertility due to large-headed multiflagellar polyploid spermatozoa · score 0.37
- Jeune syndrome · score 0.30
- external ear disease · score 0.16
- Microcephaly · score 0.14
- neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies · score 0.12
- short-rib thoracic dysplasia 6 with or without polydactyly · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LB3-F1 | alphafold | PREDICTED | 80.02 | — |
Amino-acid sequence (600 residues)
MASNHKSSAA RPVSRGGVGL TGRPPSGIRP LSGNIRVATA MPPGTARPGS RGCPIGTGGV LSSQIKVAHR PVTQQGLTGM KTGTKGPQRQ ILDKSYYLGL LRSKISELTT EVNKLQKGIE MYNQENSVYL SYEKRAETLA VEIKELQGQL ADYNMLVDKL NTNTEMEEVM NDYNMLKAQN DRETQSLDVI FTERQAKEKQ IRSVEEEIEQ EKQATDDIIK NMSFENQVKY LEMKTTNEKL LQELDTLQQQ LDSQNMKKES LEAEIAHSQV KQEAVLLHEK LYELESHRDQ MIAEDKSIGS PMEEREKLLK QIKDDNQEIA SMERQLTDTK EKINQFIEEI RQLDMDLEEH QGEMNQKYKE LKKREEHMDT FIETFEETKN QELKRKAQIE ANIVALLEHC SRNINRIEQI SSITNQELKM MQDDLNFKST EVQKSQSTAQ NLTSDIQRLQ LDLQKMELLE SKMTEEQHSL KSKIKQMTTD LEIYNDLPAL KSSGEEKIKK LHQERMILST HRNAFKKIME KQNIEYEALK TQLQENETHS QLTNLERKWQ HLEQNNFAMK EFIATKSQES DYQPIKKNVT KQIAEYNKTI VDALHSTSGN
Explore Intraflagellar transport protein 74 homolog with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets