V-type proton ATPase subunit G 3 (ATP6V1G3)

About V-type proton ATPase subunit G 3

V-type proton ATPase subunit G 3 (ATP6V1G3) is a protein from Homo sapiens identified by UniProt accession Q96LB4, 118 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	V-type proton ATPase subunit G 3
UniProt accession	Q96LB4
Gene	ATP6V1G3
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

mean corpuscular volume · score 0.42
erythrocyte count · score 0.36
mean corpuscular hemoglobin · score 0.35
C-reactive protein measurement · score 0.29
bipolar disorder · score 0.27
obsessive-compulsive disorder · score 0.27
monocyte percentage of leukocytes · score 0.27
mean reticulocyte volume · score 0.26
breast adenocarcinoma · score 0.21
neutrophil count · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96LB4-F1	alphafold	PREDICTED	92.52	—

Amino-acid sequence (118 residues)

MTSQSQGIHQ LLQAEKRAKD KLEEAKKRKG KRLKQAKEEA MVEIDQYRMQ RDKEFRLKQS KIMGSQNNLS DEIEEQTLGK IQELNGHYNK YMESVMNQLL SMVCDMKPEI HVNYRATN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards