About Sialic acid-binding Ig-like lectin 10
Sialic acid-binding Ig-like lectin 10 (SIGLEC10) is a protein
from Homo sapiens identified by UniProt accession
Q96LC7, 697 residues long.
MolForge cross-references it against 0 known binders and
149 disease associations.
Target properties
| Protein name | Sialic acid-binding Ig-like lectin 10 |
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| UniProt accession | Q96LC7 |
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| Gene | SIGLEC10 |
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| Organism | Homo sapiens |
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| Length | 697 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (149)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.26
- neoplasm · score 0.11
- common variable immunodeficiency · score 0.08
- combined immunodeficiency with skin granulomas · score 0.08
- BENTA disease · score 0.08
- classic Hodgkin lymphoma · score 0.07
- Hodgkins lymphoma · score 0.07
- gonorrhea · score 0.07
- Waldenstrom macroglobulinemia · score 0.07
- immunodeficiency 18 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LC7-F1 | alphafold | PREDICTED | 73.25 | — |
Amino-acid sequence (697 residues)
MLLPLLLSSL LGGSQAMDGR FWIRVQESVM VPEGLCISVP CSFSYPRQDW TGSTPAYGYW FKAVTETTKG APVATNHQSR EVEMSTRGRF QLTGDPAKGN CSLVIRDAQM QDESQYFFRV ERGSYVRYNF MNDGFFLKVT ALTQKPDVYI PETLEPGQPV TVICVFNWAF EECPPPSFSW TGAALSSQGT KPTTSHFSVL SFTPRPQDHN TDLTCHVDFS RKGVSAQRTV RLRVAYAPRD LVISISRDNT PALEPQPQGN VPYLEAQKGQ FLRLLCAADS QPPATLSWVL QNRVLSSSHP WGPRPLGLEL PGVKAGDSGR YTCRAENRLG SQQRALDLSV QYPPENLRVM VSQANRTVLE NLGNGTSLPV LEGQSLCLVC VTHSSPPARL SWTQRGQVLS PSQPSDPGVL ELPRVQVEHE GEFTCHARHP LGSQHVSLSL SVHYSPKLLG PSCSWEAEGL HCSCSSQASP APSLRWWLGE ELLEGNSSQD SFEVTPSSAG PWANSSLSLH GGLSSGLRLR CEAWNVHGAQ SGSILQLPDK KGLISTAFSN GAFLGIGITA LLFLCLALII MKILPKRRTQ TETPRPRFSR HSTILDYINV VPTAGPLAQK RNQKATPNSP RTPLPPGAPS PESKKNQKKQ YQLPSFPEPK SSTQAPESQE SQEELHYATL NFPGVRPRPE ARMPKGTQAD YAEVKFQ
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