About Bcl-2-modifying factor
Bcl-2-modifying factor (BMF) is a protein
from Homo sapiens identified by UniProt accession
Q96LC9, 184 residues long.
MolForge cross-references it against 0 known binders and
237 disease associations.
Target properties
| Protein name | Bcl-2-modifying factor |
|---|
| UniProt accession | Q96LC9 |
|---|
| Gene | BMF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 184 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (237)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- vital capacity · score 0.44
- sex hormone-binding globulin measurement · score 0.43
- lymphocyte count · score 0.41
- FEV/FVC ratio · score 0.40
- triglyceride measurement · score 0.36
- monocyte percentage of leukocytes · score 0.36
- chronic lymphocytic leukemia · score 0.35
- monocyte count · score 0.34
- serum alanine aminotransferase measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LC9-F1 | alphafold | PREDICTED | 61.44 | — |
Amino-acid sequence (184 residues)
MEPSQCVEEL EDDVFQPEDG EPVTQPGSLL SADLFAQSLL DCPLSRLQLF PLTHCCGPGL RPTSQEDKAT QTLSPASPSQ GVMLPCGVTE EPQRLFYGNA GYRLPLPASF PAVLPIGEQP PEGQWQHQAE VQIARKLQCI ADQFHRLHVQ QHQQNQNRVW WQILLFLHNL ALNGEENRNG AGPR
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