About Zeta-sarcoglycan
Zeta-sarcoglycan (SGCZ) is a protein
from Homo sapiens identified by UniProt accession
Q96LD1, 299 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Zeta-sarcoglycan |
|---|
| UniProt accession | Q96LD1 |
|---|
| Gene | SGCZ |
|---|
| Organism | Homo sapiens |
|---|
| Length | 299 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- body mass index · score 0.44
- mathematical ability · score 0.42
- self reported educational attainment · score 0.40
- body fat percentage · score 0.38
- neuroticism measurement · score 0.37
- adolescent idiopathic scoliosis · score 0.36
- type 2 diabetes mellitus · score 0.33
- sleep duration · score 0.33
- fat body mass · score 0.33
- gut microbiome measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LD1-F1 | alphafold | PREDICTED | 80.54 | — |
Amino-acid sequence (299 residues)
MTREQYILAT QQNNLPRTEN AQLYPVGIYG WRKRCLYFFV LLLLVTMIVN LAMTIWILKV MNFTVDGMGN LRVTKKGIRL EGISEFLLPL YVKEIHSRKD SPLVLQSDRN VTVNARNHMG QLTGQLTIGA DAVEAQCKRF EVRASEDGRV LFSADEDEIT IGAEKLKVTG TEGAVFGHSV ETPHIRAEPS QDLRLESPTR SLIMEAPRGV QVSAAAGDFK ATCRKELHLQ STEGEIFLNA ETIKLGNLPT GSFSSSSPSS SSSRQTVYEL CVCPNGKLYL SPAGVGSTCQ SSSNICLWS
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