About Sentrin-specific protease 8
Sentrin-specific protease 8 (SENP8) is a protein
from Homo sapiens identified by UniProt accession
Q96LD8, 212 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Sentrin-specific protease 8 |
|---|
| UniProt accession | Q96LD8 |
|---|
| Gene | SENP8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 212 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (79)
Diseases linked to this target (Open Targets).
- ovarian cancer · score 0.18
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.18
- erythrocyte count · score 0.14
- Neurodevelopmental abnormality · score 0.11
- body height · score 0.11
- retinitis pigmentosa · score 0.11
- clear cell renal carcinoma · score 0.10
- red blood cell density measurement · score 0.10
- age-related macular degeneration · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LD8-F1 | alphafold | PREDICTED | 96.74 | — |
Amino-acid sequence (212 residues)
MDPVVLSYMD SLLRQSDVSL LDPPSWLNDH IIGFAFEYFA NSQFHDCSDH VSFISPEVTQ FIKCTSNPAE IAMFLEPLDL PNKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS HSRSNSVHAK QVAEKLEAFL GRKGDKLAFV EEKAPAQQNS YDCGMYVICN TEALCQNFFR QQTESLLQLL TPAYITKKRG EWKDLITTLA KK
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