Heat shock transcription factor, Y-linked (HSFY1)

About Heat shock transcription factor, Y-linked

Heat shock transcription factor, Y-linked (HSFY1) is a protein from Homo sapiens identified by UniProt accession Q96LI6, 401 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Heat shock transcription factor, Y-linked
UniProt accession	Q96LI6
Gene	HSFY1
Organism	Homo sapiens
Length	401 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

azoospermia · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.05
partial chromosome Y deletion · score 0.05
deafness · score 0.05
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.05
deafness-infertility syndrome · score 0.05
spermatogenic failure 61 · score 0.05
spermatogenic failure 3 · score 0.05
spermatogenic failure 55 · score 0.05
spermatogenic failure 59 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96LI6-F1	alphafold	PREDICTED	57.69	—

Amino-acid sequence (401 residues)

MAHVSSETQD VSPKDELTAS EASTRSPLCE HTFPGDSDLR SMIEEHAFQV LSQGSLLESP SYTVCVSEPD KDDDFLSLNF PRKLWKIVES DQFKSISWDE NGTCIVINEE LFKKEILETK APYRIFQTDA IKSFVRQLNL YGFSKIQQNF QRSAFLATFL SEEKESSVLS KLKFYYNPNF KRGYPQLLVR VKRRIGVKNA SPISTLFNED FNKKHFRAGA NMENHNSALA AEASEESLFS ASKNLNMPLT RESSVRQIIA NSSVPIRSGF PPPSPSTSVG PSEQIATDQH AILNQLTTIH MHSHSTYMQA RGHIVNFITT TTSQYHIISP LQNGYFGLTV EPSAVPTRYP LVSVNEAPYR NMLPAGNPWL QMPTIADRSA APHSRLALQP SPLDKYHPNY N

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards