Apolipoprotein L domain-containing protein 1 (APOLD1)

About Apolipoprotein L domain-containing protein 1

Apolipoprotein L domain-containing protein 1 (APOLD1) is a protein from Homo sapiens identified by UniProt accession Q96LR9, 279 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Apolipoprotein L domain-containing protein 1
UniProt accession	Q96LR9
Gene	APOLD1
Organism	Homo sapiens
Length	279 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

bleeding disorder, vascular-type · score 0.45
systolic blood pressure · score 0.42
lymphocyte count · score 0.40
C-reactive protein measurement · score 0.40
appendicular lean mass · score 0.39
smoking status measurement · score 0.37
leukocyte count · score 0.36
hypertension · score 0.36
body height · score 0.35
platelet count · score 0.35

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96LR9-F1	alphafold	PREDICTED	60.16	—

Amino-acid sequence (279 residues)

MFRAPCHRLR ARGTRKARAG AWRGCTFPCL GKGMERPAAR EPHGPDALRR FQGLLLDRRG RLHGQVLRLR EVARRLERLR RRSLVANVAG SSLSATGALA AIVGLSLSPV TLGTSLLVSA VGLGVATAGG AVTITSDLSL IFCNSRELRR VQEIAATCQD QMREILSCLE FFCRWQGCGD RQLLQCGRNA SIALYNSVYF IVFFGSRGFL IPRRAEGDTK VSQAVLKAKI QKLAESLESC TGALDELSEQ LESRVQLCTK SSRGHDLKIS ADQRAGLFF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards