Sphingomyelin synthase-related protein 1 (SAMD8)

About Sphingomyelin synthase-related protein 1

Sphingomyelin synthase-related protein 1 (SAMD8) is a protein from Homo sapiens identified by UniProt accession Q96LT4, 415 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Sphingomyelin synthase-related protein 1
UniProt accession	Q96LT4
Gene	SAMD8
Organism	Homo sapiens
Length	415 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

self reported educational attainment · score 0.30
blood protein measurement · score 0.24
unipolar depression · score 0.23
body mass index · score 0.23
refractive error measurement · score 0.23
smoking status measurement · score 0.23
smoking initiation · score 0.23
body fat percentage · score 0.13
high density lipoprotein cholesterol measurement · score 0.12
insomnia measurement · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96LT4-F1	alphafold	PREDICTED	79.48	—

Amino-acid sequence (415 residues)

MAGPNQLCIR RWTTKHVAVW LKDEGFFEYV DILCNKHRLD GITLLTLTEY DLRSPPLEIK VLGDIKRLML SVRKLQKIHI DVLEEMGYNS DSPMGSMTPF ISALQSTDWL CNGELSHDCD GPITDLNSDQ YQYMNGKNKH SVRRLDPEYW KTILSCIYVF IVFGFTSFIM VIVHERVPDM QTYPPLPDIF LDSVPRIPWA FAMTEVCGMI LCYIWLLVLL LHKHRSILLR RLCSLMGTVF LLRCFTMFVT SLSVPGQHLQ CTGKIYGSVW EKLHRAFAIW SGFGMTLTGV HTCGDYMFSG HTVVLTMLNF FVTEYTPRSW NFLHTLSWVL NLFGIFFILA AHEHYSIDVF IAFYITTRLF LYYHTLANTR AYQQSRRARI WFPMFSFFEC NVNGTVPNEY CWPFSKPAIM KRLIG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards