About Guanine nucleotide exchange factor C9orf72
Guanine nucleotide exchange factor C9orf72 (C9orf72) is a protein
from Homo sapiens identified by UniProt accession
Q96LT7, 481 residues long.
MolForge cross-references it against 0 known binders and
591 disease associations.
Target properties
| Protein name | Guanine nucleotide exchange factor C9orf72 |
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| UniProt accession | Q96LT7 |
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| Gene | C9orf72 |
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| Organism | Homo sapiens |
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| Length | 481 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (591)
Diseases linked to this target (Open Targets).
- frontotemporal dementia and/or amyotrophic lateral sclerosis 1 · score 0.57
- amyotrophic lateral sclerosis · score 0.56
- Amyotrophic lateral sclerosis · score 0.39
- frontotemporal dementia with motor neuron disease · score 0.37
- Huntington disease-like syndrome due to C9ORF72 expansions · score 0.37
- sporadic amyotrophic lateral sclerosis · score 0.32
- mean platelet volume · score 0.28
- blood protein measurement · score 0.27
- cathepsin L1 measurement · score 0.25
- body mass index · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LT7-F1 | alphafold | PREDICTED | 83.41 | — |
Amino-acid sequence (481 residues)
MSTLCPPPSP AVAKTEIALS GKSPLLAATF AYWDNILGPR VRHIWAPKTE QVLLSDGEIT FLANHTLNGE ILRNAESGAI DVKFFVLSEK GVIIVSLIFD GNWNGDRSTY GLSIILPQTE LSFYLPLHRV CVDRLTHIIR KGRIWMHKER QENVQKIILE GTERMEDQGQ SIIPMLTGEV IPVMELLSSM KSHSVPEEID IADTVLNDDD IGDSCHEGFL LNAISSHLQT CGCSVVVGSS AEKVNKIVRT LCLFLTPAER KCSRLCEAES SFKYESGLFV QGLLKDSTGS FVLPFRQVMY APYPTTHIDV DVNTVKQMPP CHEHIYNQRR YMRSELTAFW RATSEEDMAQ DTIIYTDESF TPDLNIFQDV LHRDTLVKAF LDQVFQLKPG LSLRSTFLAQ FLLVLHRKAL TLIKYIEDDT QKGKKPFKSL RNLKIDLDLT AEGDLNIIMA LAEKIKPGLH SFIFGRPFYT SVQERDVLMT F
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