About Myelin regulatory factor-like protein
Myelin regulatory factor-like protein (MYRFL) is a protein
from Homo sapiens identified by UniProt accession
Q96LU7, 910 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Myelin regulatory factor-like protein |
|---|
| UniProt accession | Q96LU7 |
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| Gene | MYRFL |
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| Organism | Homo sapiens |
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| Length | 910 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.32
- diastolic blood pressure · score 0.30
- FEV/FVC ratio · score 0.23
- body height · score 0.09
- forced expiratory volume · score 0.09
- Barrett's esophagus · score 0.06
- Crohn's disease · score 0.04
- Skull Fractures · score 0.04
- platelet component distribution width · score 0.03
- Colon Sessile Serrated Adenoma/Polyp · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LU7-F1 | alphafold | PREDICTED | 67.21 | — |
Amino-acid sequence (910 residues)
MDVVGENEAL QQFFEAQGAN GTLENPALDT SLLEEFLGND FDLGALQRQL PDTPPYSASD SCSPPQVKGA CYPTLRPTAG RTPAPFLHPT AAPAMPPMHP LQSTSGMGDS CQIHGGFHSC HSNASHLATP LDQSVSSHLG IGCSYPQQPL CHSPGASLPP TKKRKCTQAL EDSGECRVWA CHCRPMTSRS RSSEVQDPDS EGQNRMPTDQ CSPALKWQPC HSVPWHSLLN SHYEKLPDVG YRVVTDKGFN FSPADEAFVC QKKNHFQITI HIQVWGSPKF VETEMGLKPI EMFYLKVFGT KVEATNQIIA IEQSQADRSK KIFNPVKIDL LADQVTKVTL GRLHFSETTA NNMRKKGKPN PDQRYFMLVV GLYAANQDQF YLLSAHISER IIVRASNPGQ FENDSDALWQ RGQVPESIVC HGRVGINTDA PDEALVVCGN MKVMGTIMHP SDSRAKQNIQ EVDTNEQLKR IAQMRIVEYD YKPEFASAMG INTAHQTGMI AQEVQEILPR AVREVGDVTC GNGETLENFL MVDKDQIFME NVGAVKQLCK LTNNLEERIE ELEIWNRKLA RLKRLSSWKS SASEASTISK SSRAVSASSP RRAVHKKNNK VYFSGKRQAC PNWVFQTLVI TLIAVMAFCA LTIVALYILS LKDQDRRVPN LPPSNITSSQ EPALLPTASS SAPNTSLVTT PASLQVPEIT FCEILPCQET YCCPIRGMKE VSSSPVQRQS EEKEFHQRRW SEDKSKSVLA RNALSGPDWE SDWIDTTISS IQIMEIQQII DHQYCIQSLQ CGSGNYNYNI PVNKHTPTNV KFSLEINTTE PLIVFQCKFT LGNICFHSKR GTKGLESHRE ISQEMTQGYQ HIWSLPVAPF SDSMFHFRVA APDLADCSTD PYFAGIFFTD YFFYFYRRCA
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