About DNA-directed primase/polymerase protein
DNA-directed primase/polymerase protein (PRIMPOL) is a protein
from Homo sapiens identified by UniProt accession
Q96LW4, 560 residues long.
MolForge cross-references it against 0 known binders and
137 disease associations.
Target properties
| Protein name | DNA-directed primase/polymerase protein |
|---|
| UniProt accession | Q96LW4 |
|---|
| Gene | PRIMPOL |
|---|
| Organism | Homo sapiens |
|---|
| Length | 560 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (137)
Diseases linked to this target (Open Targets).
- Myopia · score 0.49
- neurodegenerative disease · score 0.47
- adolescent idiopathic scoliosis · score 0.25
- mucocutaneous lymph node syndrome · score 0.21
- Sleep Disorder · score 0.14
- caspase-3 measurement · score 0.11
- neoplasm · score 0.07
- cancer · score 0.06
- essential tremor · score 0.06
- azoospermia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96LW4-F1 | alphafold | PREDICTED | 74.02 | — |
Amino-acid sequence (560 residues)
MNRKWEAKLK QIEERASHYE RKPLSSVYRP RLSKPEEPPS IWRLFHRQAQ AFNFVKSCKE DVHVFALECK VGDGQRIYLV TTYAEFWFYY KSRKNLLHCY EVIPENAVCK LYFDLEFNKP ANPGADGKKM VALLIEYVCK ALQELYGVNC SAEDVLNLDS STDEKFSRHL IFQLHDVAFK DNIHVGNFLR KILQPALDLL GSEDDDSAPE TTGHGFPHFS EAPARQGFSF NKMFTEKATE ESWTSNSKKL ERLGSAEQSS PDLSFLVVKN NMGEKHLFVD LGVYTRNRNF RLYKSSKIGK RVALEVTEDN KFFPIQSKDV SDEYQYFLSS LVSNVRFSDT LRILTCEPSQ NKQKGVGYFN SIGTSVETIE GFQCSPYPEV DHFVLSLVNK DGIKGGIRRW NYFFPEELLV YDICKYRWCE NIGRAHKSNN IMILVDLKNE VWYQKCHDPV CKAENFKSDC FPLPAEVCLL FLFKEEEEFT TDEADETRSN ETQNPHKPSP SRLSTGASAD AVWDNGIDDA YFLEATEDAE LAEAAENSLL SYNSEVDEIP DELIIEVLQE
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