About Cyclic nucleotide-binding domain-containing protein 2
Cyclic nucleotide-binding domain-containing protein 2 (CNBD2) is a protein
from Homo sapiens identified by UniProt accession
Q96M20, 576 residues long.
MolForge cross-references it against 0 known binders and
123 disease associations.
Target properties
| Protein name | Cyclic nucleotide-binding domain-containing protein 2 |
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| UniProt accession | Q96M20 |
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| Gene | CNBD2 |
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| Organism | Homo sapiens |
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| Length | 576 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (123)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.39
- fat body mass · score 0.33
- appendicular lean mass · score 0.28
- whole body water mass · score 0.18
- body height · score 0.15
- base metabolic rate measurement · score 0.10
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- isolated congenital hypogonadotropic hypogonadism · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96M20-F1 | alphafold | PREDICTED | 69.73 | — |
Amino-acid sequence (576 residues)
MRRHMVTYAW QLLKKELGLY QLAMDIIIMI RVCKMFRQGL RGFREYQIIE TAHWKHPIFS FWDKKMQSRV TFDTMDFIAE EGHFPPKAIQ IMQKKPSWRT EDEIQAVCNI LQVLDSYRNY AEPLQLLLAK VMRFERFGRR RVIIKKGQKG NSFYFIYLGT VAITKDEDGS SAFLDPHPKL LHKGSCFGEM DVLHASVRRS TIVCMEETEF LVVDREDFFA NKLDQEVQKD AQYRFEFFRK MELFASWSDE KLWQLVAMAK IERFSYGQLI SKDFGESPFI MFISKGSCEV LRLLDLGASP SYRRWIWQHL ELIDGRPLKT HLSEYSPMER FKEFQIKSYP LQDFSSLKLP HLKKAWGLQG TSFSRKIRTS GDTLPKMLGP KIQSRPAQSI KCAMINIKPG ELPKEAAVGA YVKVHTVEQG EILGLHQAFL PEGECDTRPL ILMSLGNELI RIRKEIFYEL IDNDDEMIKK LLKLNIAFPS DEDMCQKFLQ QNSWNIFRKD LLQLLVEPCQ SQLFTPNRPK KREIYNPKSV VLDLCSINKT TKPRYPIFMA PQKYLPPLRI VQAIKAPRYK IRELLA
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