About Adenylate kinase 7
Adenylate kinase 7 (AK7) is a protein
from Homo sapiens identified by UniProt accession
Q96M32, 723 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | Adenylate kinase 7 |
|---|
| UniProt accession | Q96M32 |
|---|
| Gene | AK7 |
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| Organism | Homo sapiens |
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| Length | 723 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- spermatogenic failure 27 · score 0.57
- C-reactive protein measurement · score 0.43
- urate measurement · score 0.38
- non-syndromic male infertility due to sperm motility disorder · score 0.37
- electrocardiography · score 0.31
- maximal oxygen uptake measurement · score 0.31
- neurodegenerative disease · score 0.30
- neuroinflammatory disorder · score 0.17
- primary ciliary dyskinesia · score 0.13
- appendicular lean mass · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96M32-F1 | alphafold | PREDICTED | 82.22 | — |
Amino-acid sequence (723 residues)
MAEEEETAAL TEKVIRTQRV FINLLDSYSS GNIGKFLSNC VVGASLEEIT EEEEEEDENK SAMLEASSTK VKEGTFQIVG TLSKPDSPRP DFAVETYSAI SREDLLMRLL ECDVIIYNIT ESSQQMEEAI WAVSALSEEV SHFEKRKLFI LLSTVMTWAR SKALDPEDSE VPFTEEDYRR RKSHPNFLDH INAEKMVLKF GKKARKFAAY VVAAGLQYGA EGGMLHTFFK MAWLGEIPAL PVFGDGTNVI PTIHVLDLAG VIQNVIDHVP KPHYLVAVDE SVHTLEDIVK CISKNTGPGK IQKIPRENAY LTKDLTQDCL DHLLVNLRME ALFVKENFNI RWAAQTGFVE NINTILKEYK QSRGLMPIKI CILGPPAVGK SSIAKELANY YKLHHIQLKD VISEAIAKLE AIVAPNDVGE GEEEVEEEEE EENVEDAQEL LDGIKESMEQ NAGQLDDQYI IRFMKEKLKS MPCRNQGYIL DGFPKTYDQA KDLFNQEDEE EEDDVRGRMF PFDKLIIPEF VCALDASDEF LKERVINLPE SIVAGTHYSQ DRFLRALSNY RDINIDDETV FNYFDELEIH PIHIDVGKLE DAQNRLAIKQ LIKEIGEPRN YGLTDEEKAE EERKAAEERL AREAAEEAER EHQEAVEMAE KIARWEEWNK RLEEVKREER ELLEAQSIPL RNYLMTYVMP TLIQGLNECC NVRPEDPVDF LAEYLFKNNP EAQ
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