Protein FAM227B (FAM227B)

About Protein FAM227B

Protein FAM227B (FAM227B) is a protein from Homo sapiens identified by UniProt accession Q96M60, 508 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.

Target properties

Protein name	Protein FAM227B
UniProt accession	Q96M60
Gene	FAM227B
Organism	Homo sapiens
Length	508 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (40)

Diseases linked to this target (Open Targets).

serum gamma-glutamyl transferase measurement · score 0.41
serum alanine aminotransferase measurement · score 0.39
apolipoprotein B measurement · score 0.38
aspartate aminotransferase measurement · score 0.36
low density lipoprotein cholesterol measurement · score 0.30
fibroblast growth factor 7 measurement · score 0.30
type 2 diabetes mellitus · score 0.29
human papilloma virus infection · score 0.29
oral cavity cancer · score 0.29
FEV/FVC ratio · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96M60-F1	alphafold	PREDICTED	70.69	—

Amino-acid sequence (508 residues)

MAGQRTCQRR SSRAGPGKMQ EPPKSIEEFL KFQNWDYWPR EIHFRDDDKW SCTLKKIKED SSFVSIYTHL WENVPRIFEA LLIMESKLKE YSLILQNHTS EIFKWKSMIS ETSSYRKLER YGEFLKKYHK KKKIMLSDEM ETEKNIEGCS FTGFKANELT QLPRHLDAEQ IYLFILKAHN FDERVFKIWK THFLSEASIA LLHDSFWWWF LHKFRPDREN QDCLFDRISE SYVTLFMSIP LSRKDAFFQI YPDCLAQAIY ATFHEAFPES SYLFNDEFKE DLGNNIFLWC SGLKPQKGFW IHWKLKELST TTIHGSKKAP AKSVKERIAD SQEHISTSID FNIIKILNNP RAYTLPISKE ESRLSRLATK SHYSSTGPEF NRVLFNFGGQ SPLILYYLKM HELAGISKAP KKTKIKLTKI FQEPLPAPTY RDVIKEAKRQ FARNQKDFRI LQAKATKKPH EVKQDFEKFL HKLRSEAEIE RECVASLSSS SSSSPSSTDN YNFEEEEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards