About Leucine-rich repeat and guanylate kinase domain-containing protein
Leucine-rich repeat and guanylate kinase domain-containing protein (LRGUK) is a protein
from Homo sapiens identified by UniProt accession
Q96M69, 825 residues long.
MolForge cross-references it against 0 known binders and
149 disease associations.
Target properties
| Protein name | Leucine-rich repeat and guanylate kinase domain-containing protein |
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| UniProt accession | Q96M69 |
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| Gene | LRGUK |
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| Organism | Homo sapiens |
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| Length | 825 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (149)
Diseases linked to this target (Open Targets).
- risky sexual behaviour measurement · score 0.32
- antisocial behaviour measurement · score 0.32
- substance abuse · score 0.32
- attention deficit hyperactivity disorder · score 0.32
- smoking status measurement · score 0.30
- insulin like growth factor measurement · score 0.18
- mathematical ability · score 0.17
- vitamin D measurement · score 0.13
- self reported educational attainment · score 0.13
- neurodegenerative disease · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96M69-F1 | alphafold | PREDICTED | 70.10 | — |
Amino-acid sequence (825 residues)
MATSERALLR TRAASLLRGL GRSRTGARSL QFRAEKERQP CWSFPMGQKT KGSSNIASSY LLQQLMHRYQ ELDSDGDEDQ GEGEAGSEES SESEMLNLEE EFDGVLREEA VAKALHHLGR SGSGTEQVYL NLTLSGCNLI DVSILCGYVH LQKLDLSANK IEDLSCVSCM PYLLELNASQ NNLTTFFNFK PPKNLKKADF SHNQISEICD LSAYHALTKL ILDGNEIEEI SGLEMCNNLI HLSLANNKIT TINGLNKLPI KILCLSNNQI EMITGLEDLK ALQNLDLSHN QISSLQGLEN HDLLEVINLE DNKIAELREI EYIKNLPILR VLNLLENPIQ EKSEYWFFVI FMLLRLTELD QKKIKVEEKV SAVNKYDPPP EVVAAQDHLT HVVNSVMQPQ RIFDSTLPSL DAPYPMLILA GPEACGKREL AHRLCRQFST YFRYGACHTT RPPYFGEGDR VDYHFISQDV FDEMVNMGKF ILTFSYGNHK YGLNRDTVEG IARDGLASCI HMEIEGVRSL KYSYFEPRYI LVVPMNKEKY EGYLRRKGLF SRAEIEFAVS RVDLYIKINQ NFPGYFDEVI NADDLDVAYQ KLSQLIREYL GLTEEPAKSL ATTADVKTSH LKPEAHPTKY ISSNMGDFLH STDRNYLIKF WAKLSAKKTP AERDSIHRQH EAARQALMGR IRPDHTLLFQ RGPVPAPLTS GLHYYTTLEE LWKSFDLCED YFKPPFGPYP EKSGKDSLVS MKCSLFRFCP WSKELPFQPP EGSISSHLGS GASDSETEET RKALPIQSFS HEKESHQHRQ HSVPVISRPG SNVKPTLPPI PQGRR
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