About Coiled-coil domain-containing protein 138
Coiled-coil domain-containing protein 138 (CCDC138) is a protein
from Homo sapiens identified by UniProt accession
Q96M89, 665 residues long.
MolForge cross-references it against 0 known binders and
15 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 138 |
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| UniProt accession | Q96M89 |
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| Gene | CCDC138 |
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| Organism | Homo sapiens |
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| Length | 665 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (15)
Diseases linked to this target (Open Targets).
- acne · score 0.25
- hair shape measurement · score 0.20
- birth weight · score 0.17
- lobe attachment · score 0.14
- androgenetic alopecia · score 0.13
- balding measurement · score 0.10
- facial hair thickness measurement · score 0.08
- synophrys measurement · score 0.08
- hair morphology · score 0.07
- hyperthyroidism · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96M89-F1 | alphafold | PREDICTED | 72.46 | — |
Amino-acid sequence (665 residues)
MEPRVVKPPG QDLVVESLKS RYGLGGSCPD EYDFSNFYQS KYKRRTLTSP GDLDIYSGDK VGSSLKYSDE SKHCRTPLGS LFKHVNVNCL DDELDSFHDL KKQETEEELI ENDYRVSTSK ITKQSFKEIE KVALPTNTTS SRPRTECCSD AGDSPLKPVS CPKSKASDKR SLLPHQISQI YDELFQIHLK LQCETAAQQK FAEELQKRER FLLEREQLLF RHENALSKIK GVEEEVLTRF QIIKEQHDAE VEHLTEVLKE KNKETKRLRS SFDALKELND TLKKQLNEAS EENRKIDIQA KRVQARLDNL QRKYEFMTIQ RLKGSSHAVH EMKSLKQEKA PVSKTYKVPL NGQVYELLTV FMDWISDHHL SKVKHEESGM DGKKPQLKFA SQRNDIQEKC VKLLPLMTEQ LQWMPFVNIK LHEPFVKFIY WSLRQLDAGA QHSTMTSTLR RLGEDIFKGV VTKGIQDNSP QHSVENKPKT AAFFKSSNLP LRFLSTLIVL KTVTQADYLA QAFDSLCLDL KTEEGKTLFL EYQAVPVILS HLRISSKGLL SNVIDSLLQM TVESKSLQPF LEACSNSLFF RTCSVLLRAP KLDLQILEKL SIILQKLSKI KSNKKLFELF TIHLMLQEIQ RTTNPEHAFL CINLNSTLFN LGLTKCNSLV SSASP
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