About Cilia- and flagella-associated protein 53
Cilia- and flagella-associated protein 53 (CFAP53) is a protein
from Homo sapiens identified by UniProt accession
Q96M91, 514 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | Cilia- and flagella-associated protein 53 |
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| UniProt accession | Q96M91 |
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| Gene | CFAP53 |
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| Organism | Homo sapiens |
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| Length | 514 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (147)
Diseases linked to this target (Open Targets).
- Heterotaxia · score 0.62
- visceral heterotaxy · score 0.47
- Dextrocardia · score 0.45
- Heterotaxy · score 0.40
- Situs inversus totalis · score 0.37
- transposition of the great arteries · score 0.37
- poisoning · score 0.28
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.27
- genetic disorder · score 0.19
- 3-hydroxypropylmercapturic acid measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96M91-F1 | alphafold | PREDICTED | 86.00 | — |
Amino-acid sequence (514 residues)
MYSQRFGTVQ REVKGPTPKV VIVRSKPPKG QGAEHHLERI RRSHQKHNAI LASIKSSERD RLKAEWDQHN DCKILDSLVR ARIKDAVQGF IINIEERRNK LRELLALEEN EYFTEMQLKK ETIEEKKDRM REKTKLLKEK NEKERQDFVA EKLDQQFRER CEELRVELLS IHQKKVCEER KAQIAFNEEL SRQKLVEEQM FSKLWEEDRL AKEKREAQEA RRQKELMENT RLGLNAQITS IKAQRQATQL LKEEEARLVE SNNAQIKHEN EQDMLKKQKA KQETRTILQK ALQERIEHIQ QEYRDEQDLN MKLVQRALQD LQEEADKKKQ KREDMIREQK IYHKYLAQRR EEEKAQEKEF DRILEEDKAK KLAEKDKELR LEKEARRQLV DEVMCTRKLQ VQEKLQREAK EQEERAMEQK HINESLKELN CEEKENFARR QRLAQEYRKQ LQMQIAYQQQ SQEAEKEEKR REFEAGVAAN KMCLDKVQEV LSTHQVLPQN IHPMRKACPS KLPP
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