About Adenosine deaminase domain-containing protein 1
Adenosine deaminase domain-containing protein 1 (ADAD1) is a protein
from Homo sapiens identified by UniProt accession
Q96M93, 576 residues long.
MolForge cross-references it against 0 known binders and
172 disease associations.
Target properties
| Protein name | Adenosine deaminase domain-containing protein 1 |
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| UniProt accession | Q96M93 |
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| Gene | ADAD1 |
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| Organism | Homo sapiens |
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| Length | 576 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (172)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.27
- asthma · score 0.25
- mean platelet volume · score 0.22
- allergic disease · score 0.21
- seasonal allergic rhinitis · score 0.20
- allergic rhinitis · score 0.20
- Eczematoid dermatitis · score 0.19
- depressive symptom measurement · score 0.19
- unipolar depression · score 0.18
- childhood onset asthma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96M93-F1 | alphafold | PREDICTED | 77.83 | — |
Amino-acid sequence (576 residues)
MASNNHWFQS SQVPSFAQML KKNLPVQPAT KTITTPTGWS SESYGLSKMA SKVTQVTGNF PEPLLSKNLS SISNPVLPPK KIPKEFIMKY KRGEINPVSA LHQFAQMQRV QLDLKETVTT GNVMGPYFAF CAVVDGIQYK TGLGQNKKES RSNAAKLALD ELLQLDEPEP RILETSGPPP FPAEPVVLSE LAYVSKVHYE GRHIQYAKIS QIVKERFNQL ISNRSEYLKY SSSLAAFIIE RAGQHEVVAI GTGEYNYSQD IKPDGRVLHD THAVVTARRS LLRYFYRQLL LFYSKNPAMM EKSIFCTEPT SNLLTLKQNI NICLYMNQLP KGSAQIKSQL RLNPHSISAF EANEELCLHV AVEGKIYLTV YCPKDGVNRI SSMSSSDKLT RWEVLGVQGA LLSHFIQPVY ISSILIGDGN CSDTRGLEIA IKQRVDDALT SKLPMFYLVN RPHISLVPSA YPLQMNLEYK FLSLNWAQGD VSLEIVDGLS GKITESSPFK SGMSMASRLC KAAMLSRFNL LAKEAKKELL EAGTYHAAKC MSASYQEAKC KLKSYLQQHG YGSWIVKSPC IEQFNM
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